Blood transfusion therapy remains an indispensable intervention in the management of sickle cell disease (SCD), mitigating life‐threatening complications such as vaso‐occlusive crises and stroke. The ...

Investigators said the benefits appeared relatively early in treatment for many patients and persisted throughout the study period. New clinical trial data suggest a first-in-class humanized ...

A meta-analysis on complement inhibitors in the management of paroxysmal nocturnal hemoglobinuria (PNH) reveals an association between these interventions and positive treatment outcomes. Complement ...

Among people with sickle cell disease—an inherited blood disorder—acute chest syndrome (ACS) is the leading cause of death. The condition is the result of red blood cells becoming stiff, sticky, and ...

Dr Austin Kulasekararaj of King’s College Hospital, London University, UK, the lead investigator on the long-term CONSERVE safety and efficacy study of nomacopan in patients with PNH commented, “The ...

Sickle cell disease (SCD) is a group of inherited blood disorders. Affected hemoglobin inside your red blood cells (RBCs) causes them to lose their flexible donut shape and take on a “C” shape. These ...

A strategy of administering a transfusion only when the hemoglobin level falls below 7 or 8 g per deciliter has been widely adopted. However, patients with acute myocardial infarction may benefit from ...