Before a cell can divide, it has to precisely duplicate its entire genetic information. However, the DNA in the cell exists as part of a DNA-protein complex known as chromatin. For this purpose, the ...

Scientists reveal a hidden second layer of human DNA, showing how genome folding controls genes and influences disease development.

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

Scientists used a bacterial system called retron to turn DNA into a programmable tool inside living cells, enabling gene ...

The human genome has to be carefully organized so it will fit inside of the nuclei of cells, while also remaining accessible to the cellular machinery that works to express the right genes at the ...

Researchers at the University of Bristol have caught DNA-copying enzymes generating long stretches of genetic code without ...

CDCA7, whose mutations alter DNA methylation pattern and cause immunodeficiency, is a novel sensor for a special class of methylated DNA. DNA methylation is a process in which a methyl group is ...

Most of the cells in our body carry the genome, and those cells are constantly bombarded with environmental influences including UV rays, pollution, alcohol, and other exposures that can damage the ...

Tampa (BLOOM) – Understanding the intricate process of aging has been a subject of fascination for scientists and researchers. While aging is a natural part of life, recent studies have shed light on ...

Researchers discovered a kinase-driven phosphorylation switch that activates DNA packaging machinery, aligning nucleosomes at ...