The engineering and functional characterization of the Fc domain are key to therapeutic antibodies’ efficacy, safety, and pharmacokinetics. The Fc domain is responsible for mediating interactions with ...
AGEN-1721 was designed as an Fc-enhanced bifunctional antibody to selectively target FAP and neutralize TGF-β via an optimized TGF-βR2 TRAP moiety fused to an engineered Fc region, with the aim of ...
(A) Structural propagation pathways originating from galactose residues within the Fc-linked glycan. (B) Galactose residues (indicated by yellow circles) suppress glycan mobility by acting as ...
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