The Seegar Lab used advanced cryogenic electron microscopy techniques to visualize the structure of the ADAM17 enzyme bound to its regulator protein, iRhom2, and identify key elements vital for its ...

Cells have a remarkable housekeeping system: proteins that are no longer needed, defective, or potentially harmful are labeled with a molecular "tag" and dismantled in the cellular recycling machinery ...

The first full-length structures of two heat shock chaperone proteins in a complex reveal the key structural region regulating their function, according to a new study from St. Jude Children's ...

C3G and IC-MPGN both cause protein deposits that reduce kidney function. Overactive proteins in the immune system lead to these different conditions. C3G and IC-MPGN are rare kidney conditions. They ...

Over the millennia, viruses have become excellent manipulators of biology. But there’s a lot that scientists don’t know about how viruses work, in part because they have relatively little insight into ...

C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN) are two rare kidney diseases. They’re both driven by activity of the complement system, which is a ...