Interleukin (IL)-1 is a prototypic proinflammatory cytokine. It is produced by numerous cell types (i.e., macrophages, synoviocytes, endothelial cells, chondrocytes, osteoclasts) and is found in ...

Sequence variants that protect against pericarditis have been discovered at a genomic locus encoding interleukin-1 immune cytokines. A newly approved drug treatment for pericarditis inhibits these ...

Researchers have identified several steps in the pathway that triggers the production of interleukin-1 beta, a key cytokine involved in the inflammatory response. Inflammation is an essential part of ...