What happens if a protein-based biotherapeutic includes unexpected isoforms? Traditional, analysis might not even reveal very similar isoforms in a biotherapeutic. So, Jonathan Bones, PhD, principal ...

Joshua C. Snyder is in the Departments of Surgery and Cell Biology, Duke University School of Medicine, Durham, North Carolina 27710, USA. Marti-Solano and colleagues set out to determine how the ...

KRAS was one of the first oncogenes to be identified, a few decades ago. It is among the most common drivers of cancer and its mutations can be detected in around 25 per cent of human tumors. The ...

Gene isoforms are different variations or versions of a gene that can be produced by alternative splicing or alternative transcription initiation and termination. These isoforms are often present in ...

New research led by the University of Exeter has shed light on the complexity of gene expression in the brain by characterizing the extent of isoform diversity in the human and mouse cortex, including ...

Our proteome is much bigger than our genome because one gene produces several variants of proteins called protein isoforms, whose disbalance is implicated in many diseases. A new bioengineered ...

Researchers have identified a new way to make opioids safer, increasing the pain-relieving properties of opioids while decreasing unwanted side effects through the spinal inhibition of a Heat shock ...

4-D separation system is expected to allow accurate mapping of proteomics data to phenotype. Scientists say a new ‘top-down’ approach to identifying individual proteins at the proteome-wide scale can ...

Correspondence to: Dr B C Nindl Military Performance Division, US Army Research Institute of Environmental Medicine, Natick, MA 1760, USA; bradley.nindl{at}na.amedd.army.mil If you wish to reuse any ...

Researchers have discovered a blood signature of protein isoforms that could potentially predict which patients may reject a new organ transplant, helping inform therapeutic decisions. The findings of ...