The protein is implicated in a wide swath of cancers, but harnessing it for drug R&D is still a major scientific challenge.

Rezetapopt showed a 44.4% response rate and durable responses over 8 months in ovarian cancer with p53 Y220C mutation, with ...

Roswell Park researchers present a two-step, mechanism-based drug strategy at AACR 2026 that selectively targets cancers with ...

The well-known cancer gene, p53, which researchers had thought was less relevant in kidney cancer, may play an important role after all – a discovery that could potentially lead to new treatments. A ...

As we age, our cells accumulate genetic changes—mutations—some of which open the door to cancer. Scientists call these ...

An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the "guardian of the genome" for its ability to repair DNA damage or destroy cancerous cells.

Researchers identified a novel mechanism by which expression of the tumor suppressor p53 paradoxically promotes liver cancer development in patients with chronic liver disease. By generating a mouse ...

The p53 gene plays an important role in cell biology as it regulates the cell cycle and halts the formation of tumors. While the gene was discovered more than four decades ago, researchers are still ...

The p53 gene is extremely important in cell biology as its role is to regulate the cell cycle and halt the formation of tumors, leading to its nickname the “tumor suppressor gene.” However, previous ...

In the 1970s, scientists knew that some viruses and chemicals caused cancer, but they didn’t know how. Arnold Levine, a biologist currently at the Institute for Advanced Study researched DNA viruses ...