Nucleic acids are complex biological molecules that store and transmit genetic information in all living organisms. They are essential for the survival and reproduction of life on Earth. The two main ...

Xeno nucleic acids are essential for the development of nucleic acid-based drugs. To be effective, they need to be able to stably bind to natural RNA (a cellular single-stranded version of the DNA, ...

As a molecular biologist, I always enjoy reading articles concerning DNA and RNA. Your excellent article in the April 3, 2023, issue of C&EN (page 18) titled “The Promise of Peptide Nucleic Acids” ...

Comparison of a single-stranded RNA and a double-stranded DNA with their corresponding nucleobases. (Image: Wikimedia Commons, CC SA 3.0) The most common type of base pairing is the Watson-Crick base ...

MicroRNAs, whose discovery was recognized with the 2025 Nobel Prize in Physiology or Medicine, are central regulators of gene ...

DNA is the poster child for high-specificity binding. As long as their base sequences match, two complementary strands of DNA can navigate through a sea of biomolecules, find each other, and hold fast ...

Disease-causing viruses such as SARS-CoV-2, hepatitis virus, and influenza virus pose serious threats to public health. To combat viral outbreaks, early detection of a virus’s presence in a population ...

This study was performed by Professor Xue-Qiang Wang’s research group at Hunan University. Aptamers, known as ̒chemical antibodies̕, can specifically recognize various targets. Therefore, they are ...