Unusual genetic code in Antarctic microbes yields rare amino acid

Researchers discover a unique genetic code in Antarctic archaea that encodes a rare amino acid, potentially advancing protein ...
eLife

Separating selection from mutation in antibody language models

This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...
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Scientists Rewrite the Genetic Code of E. Coli, and It's Drastically Different From Anything Found in Nature

The DNA of nearly all life on Earth is made up of 64 codons, each one a sequence of three nucleotide bases, the building blocks of DNA. These codons contain instructions for building amino acids, ...
Science Daily

Scientists recreate life’s first step: Linking amino acids to RNA

Researchers demonstrated how amino acids could spontaneously attach to RNA under early Earth-like conditions using thioesters, providing a long-sought clue to the origins of protein synthesis. This ...
eLife

Translational reading frame determines the pathogenicity of C-terminal frameshift deletions in MeCP2: an alternative therapeutic approach

This study offers important insight into the pathogenic basis of intragenic frameshift deletions in the carboxy-terminal domain of MECP2, which account for some Rett syndrome cases, yet similar ...