1 day ago · The official source of the latest Colts headlines, news, videos, photos, tickets, rosters, stats, schedule, and gameday information

Primetime for the Indianapolis Colts is quickly approaching, as the squad will defend home turf against the San Francisco 49ers tomorrow night from Lucas Oil Stadium.

Dec 24, 2025 · 49ers vs. Colts: Brock Purdy lights up Indy for 5 TDs, spoils Philip Rivers' season debut at home in 48-27 win Bills, Jaguars and Chargers clinch playoff spots on Colts' defeat

14 hours ago · 49ers vs. Colts live updates, highlights from 'Monday Night Football' Final: 49ers 48, Colts 27 11:19 p.m.: Purdy has come in to kneel out the clock, and the 49ers have a huge win.

8 hours ago · Colts’ loss to 49ers clinches playoff spots for Bills, Chargers, Jaguars The Buffalo Bills wrapped up their seventh straight playoff appearance Monday night with the Colts' loss.

16 hours ago · The Indianapolis Colts waived QB Brett Rypien and activated three players before their "Monday Night Football" game against the San Francisco 49ers.

Visit ESPN for Indianapolis Colts live scores, video highlights, and latest news. Find standings and the full 2025 season schedule.

14 hours ago · The Indianapolis Colts lose to the San Francisco 49ers in NFL Week 16 action on 'Monday Night Football': Score updates, highlights

Be the best Indianapolis Colts fan you can be with Bleacher Report. Keep up with the latest storylines, expert analysis, highlights, scores and more.

15 hours ago · To win the AFC South, the Colts must win out while Houston and Jacksonville lose out. If the Colts win out, they can secure a playoff spot under several complex tiebreaker scenarios. Even …